Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

Scott A. Jenks, Kevin S. Cashman, Esther Zumaquero, +20

Immunity

InflammationToll-like ReceptorsMolecular ImmunologyAutoimmune DiseaseSystemic Lupus Erythematosus +8

IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation

Esther Zumaquero, Sara L. Stone, Christopher D. Scharer, +18

eLife

Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell–Derived Cells: Universal Donor for Cell Therapy

Saidulu Mattapally, Kevin M. Pawlik, Vladimir G. Fast, +5

Journal of the American Heart Association

Cell TherapyImmunologyStem Cell BiologyCellular TherapiesPluripotent Stem Cells +20

Single-Dose Intranasal Administration of AdCOVID Elicits Systemic and Mucosal Immunity against SARS-CoV-2 and Fully Protects Mice from Lethal Challenge

R. Glenn King, Aarón Silva-Sánchez, Jessica N. Peel, +33

Vaccines

Increased gene expression of Toll‐like receptor 4 on peripheral blood mononuclear cells in patients with psoriasis

Sonia García‐Rodríguez, Salvador Arias‐Santiago, Rubén Perandrés-López, +8

Journal of the European Academy of Dermatology and Venereology

A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans

Anoma Nellore, Esther Zumaquero, Christopher D. Scharer, +14

Immunity

VaccinationDistinct SubsetHumoral ResponseImmunologyInfluenza Vaccine +7

Exosomes from human lymphoblastoid B cells express enzymatically active CD38 that is associated with signaling complexes containing CD81, Hsc-70 and Lyn

Esther Zumaquero, Pilar Muñoz, Marién Cobo, +9

Experimental Cell Research

ImmunologyImmunologic MechanismExtracellular MicrovesiclesAntigen ProcessingActive Cd38 +3

Increased CD38 expression in T cells and circulating anti-CD38 IgG autoantibodies differentially correlate with distinct cytokine profiles and disease activity in systemic lupus erythematosus patients

Esther J. Pavón, Esther Zumaquero, Antonio Rosal‐Vela, +11

Cytokine

InflammationAutoimmune DiseaseSystemic Lupus Erythematosus TreatmentLupusT Cells +10

Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 in mice

R. Glenn King, Aarón Silva-Sánchez, Jessica N. Peel, +29

ImmunologyCd4 T Cell ResponsesAntiviral DrugImmunotherapyCovid-19 +18

Altered AKT1 and MAPK1 Gene Expression on Peripheral Blood Mononuclear Cells and Correlation with T-Helper-Transcription Factors in Systemic Lupus Erythematosus Patients

Sonia García‐Rodríguez, José Luís Callejas-Rubio, Norberto Ortego‐Centeno, +6

Mediators of Inflammation

T-regulatory CellImmunologyImmunotherapySle PatientsImmune Dysregulation +14