A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

Carola G. Vinuesa, Matthew Cook, Constanza Angelucci, +12

Nature

ImmunogeneticsAutoimmune DiseaseT-regulatory CellImmune RegulationImmunology +6

TLR7 gain-of-function genetic variation causes human lupus

Grant J. Brown, Pablo F. Cañete, Hao Wang, +41

Nature

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

Di Yu, Andy Hee‐Meng Tan, Xin Hu, +9

Nature

ImmunogeneticsAllergyAutoimmune DiseaseLaboratory ImmunologyImmunology +7

Protein Profiling with Epstein-Barr Nuclear Antigen-1 Reveals an Interaction with the Herpesvirus-associated Ubiquitin-specific Protease HAUSP/USP7

Melissa N. Holowaty, Mahel Zeghouf, Hong Wu, +4

Journal of Biological Chemistry

Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation

Alvin Pratama, Roybel R. Ramiscal, Diego G. Silva, +14

Immunity

InflammationCytokineTranscriptional RegulationSignal TransductionAutoimmune Disease +11

Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus

Simon Jiang, Vicki Athanasopoulos, Julia I. Ellyard, +38

Nature Communications

MicroRNA-146a regulates ICOS–ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres

Alvin Pratama, Monika Srivastava, Naomi Williams, +9

Nature Communications

Microrna-146a Regulates Icos–icoslT-regulatory CellImmunologyGerminal CentresImmunotherapy +16

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Joanne M. Hildebrand, Maria Kauppi, Ian J. Majewski, +67

Nature Communications

The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs

Vicki Athanasopoulos, Andrew Barker, Di Yu, +11

FEBS Journal

Molecular BiologyRoquin FamilyTarget MrnasRna Binding ProteinsLong Non-coding Rna +15

Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis

Monika Srivastava, Guowen Duan, Nadia J. Kershaw, +16

Nature Communications