Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou, Amir S. Yazdi, Philippe Menu et al. · Nature · 2010 · 5.4K citations

Life Sciences, Cell Biology, Molecular Biology +12

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

Stephanie Lefèvre, Anette Knedla, Christoph Tennie et al. · Nature Medicine · 2009 · 705 citations

Medicine, Immunology, Pathology +14

Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate

Mark C. Genovese, Stanley Cohen, Larry W. Moreland et al. · Arthritis & Rheumatism · 2004 · 522 citations

Medicine, Pharmacology, Pharmacotherapy +16

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

Lieselotte Vande Walle, Nina Van Opdenbosch, Peggy Jacques et al. · Nature · 2014 · 503 citations · Full text

Veterinary Medicine, Immunology, Molecular Medicine +15

Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways

Qichao Huang, Lei Zhan, Haiyan Cao et al. · Autophagy · 2016 · 395 citations · Full text

Life Sciences, Cancer Biology, Oncology +12