FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

Prajwal Gurung, Paras Anand, R. K. Subbarao Malireddi, +7

The Journal of Immunology

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

Lieselotte Vande Walle, Nina Van Opdenbosch, Peggy Jacques, +8

Nature

ImmunologyA20 ProtectsInflammatory ArthritisInflammationNlrp3 Inflammasome +14

Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture

Nathalia M. de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, +2

Cell Death and Differentiation

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

Nina Van Opdenbosch, Prajwal Gurung, Lieselotte Vande Walle, +3

Nature Communications

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Hanne Van Gorp, Pedro Saavedra, Nathalia M. de Vasconcelos, +15

Proceedings of the National Academy of Sciences

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4

Nina Van Opdenbosch, Hanne Van Gorp, Maarten Verdonckt, +12

Cell Reports

Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5

Magdalena Matusiak, Nina Van Opdenbosch, Lieselotte Vande Walle, +3

Proceedings of the National Academy of Sciences

An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages

Nathalia Moraes de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, +4

Cell Reports

Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair

Parul Mehrotra, Sophia Maschalidi, Laura Boeckaerts, +17

Nature

Reductive StressSignal TransductionOxysterolBiochemistryLipid Peroxidation +9

<scp>GSDMD</scp> drives canonical inflammasome‐induced neutrophil pyroptosis and is dispensable for <scp>NETosis</scp>

Dhruv Chauhan, Dieter Demon, Lieselotte Vande Walle, +14

EMBO Reports

InflammationGranulocyteImmune RegulationImmunologyChronic Inflammation +5