Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Paul R. Burton, David Clayton, Lon R. Cardon, +32

Nature

Genome-wide Association StudyDisease SusceptibilityDisease EtiologyGlobal HealthGenetic Epidemiology +7

Cryopyrin activates the inflammasome in response to toxins and ATP

Sanjeev Mariathasan, David S. Weiss, Kim Newton, +7

Nature

Cell PhysiologyReductive StressSignal TransductionBiochemistryNatural Sciences +9

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Franz Bauernfeind, Gábor Horváth, Andrea Stutz, +9

The Journal of Immunology

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

Ingrid E. Wertz, Karen O’Rourke, Honglin Zhou, +10

Nature

Signal TransductionCell RegulationMolecular PathwayMolecular RegulationSignaling Pathway +9

Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice

Eric G. Lee, David L. Boone, Sophia Chai, +4

Science

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

David L. Boone, Emre E. Turer, Eric G. Lee, +9

Nature Immunology

InflammationToll-like ReceptorsMolecular ImmunologyUbiquitin-modifying Enzyme A20Allergy +8

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

Christine A. Juliana, Teresa Fernandes‐Alnemri, Seokwon Kang, +3

Journal of Biological Chemistry

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis

Robert M. Plenge, Chris Cotsapas, Leela Davies, +35

Nature Genetics

Rheumatoid DisorderRheumatologyAllelic VariantAutoimmune DiseaseRheumatic Diseases +10

BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice

James R. Burke, Mark A. Pattoli, Kurt R. Gregor, +9

Journal of Biological Chemistry

Rheumatoid arthritis association at 6q23

Wendy Thomson, Anne Barton, Xiayi Ke, +17

Nature Genetics

Rheumatoid DisorderRheumatologyAutoimmune DiseaseRheumatic DiseasesImmunology +6