Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Paul R. Burton, David Clayton, Lon R. Cardon et al. · Nature · 2007 · 9.6K citations · Full text

Genome-wide Association Study, Disease Susceptibility, Disease Etiology +9

Cryopyrin activates the inflammasome in response to toxins and ATP

Sanjeev Mariathasan, David S. Weiss, Kim Newton et al. · Nature · 2006 · 3K citations · Full text

Cell Physiology, Reductive Stress, Signal Transduction +11

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Franz Bauernfeind, Gábor Horváth, Andrea Stutz et al. · The Journal of Immunology · 2009 · 2.8K citations · Full text

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

Ingrid E. Wertz, Karen O’Rourke, Honglin Zhou et al. · Nature · 2004 · 1.8K citations

Signal Transduction, Cell Regulation, Molecular Pathway +11

Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice

Eric G. Lee, David L. Boone, Sophia Chai et al. · Science · 2000 · 1.4K citations · Full text