Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways

Qichao Huang, Lei Zhan, Haiyan Cao, +10

Autophagy

Tp53 PathwaysCell AutophagyMitophagyMitochondrial FunctionMitochondrial Dynamic +13

CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways

Jibin Li, Qichao Huang, Xiaoyu Long, +6

Journal of Hepatology

BiochemistryMedicineLiver PhysiologyHepatocellular Carcinoma CellsMetabolic Regulation +11

MCU-dependent mitochondrial Ca2+ inhibits NAD+/SIRT3/SOD2 pathway to promote ROS production and metastasis of HCC cells

Tingting Ren, H Zhang, J Wang, +9

Oncogene

Cancer ResearchMitochondrial FunctionHcc CellsCell BiologyReactive Oxygen Specie +7

Mitochondrial elongation-mediated glucose metabolism reprogramming is essential for tumour cell survival during energy stress

Jingmei Li, Qichao Huang, X Long, +9

Oncogene

Tumour Cell SurvivalSystems BiologyEnergy MetabolismMitochondrial BiogenesisMitochondrial Function +9

CD147 promotes reprogramming of glucose metabolism and cell proliferation in HCC cells by inhibiting the p53-dependent signaling pathway

Qichao Huang, Jibin Li, Jinliang Xing, +9

Journal of Hepatology

P53-dependent Signaling PathwayCell RegulationMolecular PathwayMedicineImmunology +7

Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer

Xiacheng Sun, Lei Zhan, Yibing Chen, +10

Signal Transduction and Targeted Therapy

Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors

Xia Ke, Fei Fei, Yanke Chen, +7

Carcinogenesis

ImmunologyTumor ProgressionPathologyTumor Hypoxia AdaptationEpithelial Solid Tumors +15

MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial Ca2+–Dependent Antioxidant Response

Lele Ji, Fengzhou Liu, Zhe Jing, +7

Diabetes

Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis

Bingchao Qi, Linjie He, Ya Zhao, +10

Diabetologia

Ndufs1-mediated Mitochondrial DysfunctionCardiomyopathyHeart FailureMitochondrial FunctionDiabetes +8

NPAS2 promotes cell survival of hepatocellular carcinoma by transactivating CDC25A

Peng Yuan, Jibin Li, Feng Zhou, +6

Cell Death and Disease