Concepedia

Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial <i>Pf</i> GSK3/ <i>Pf</i> PK6 with Activity against Blood Stage Parasites In Vitro

Kareem A. Galal, Anna Truong, Frank E. Kwarcinski, Chandi de Silva, Krisha Avalani, Tammy M. Havener, Michael E. Chirgwin, Eric M. Merten, Han Wee Ong, Caleb Willis,

Journal of Medicinal Chemistry · 2022 · 12 citations · 35 references

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Concepts

Abstract

GSK3 inhibitors with antiplasmodial activity can be identified and can set the stage for further optimization efforts.

References

35

Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology

Rainer Wilcken, Markus O. Zimmermann, Andreas Lange et al. · Journal of Medicinal Chemistry · 2012 · 1.3K citations · Full text

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Thousands of chemical starting points for antimalarial lead identification

Francisco‐Javier Gamo, Laura M. Sanz, Jaume Vidal et al. · Nature · 2010 · 1K citations

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Uncovering the essential genes of the human malaria parasite <i>Plasmodium falciparum</i> by saturation mutagenesis

Min Zhang, Chengqi Wang, Thomas D. Otto et al. · Science · 2018 · 1K citations · Full text

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Evidence of Artemisinin-Resistant Malaria in Africa

Betty Balikagala, Naoyuki Fukuda, Mie Ikeda et al. · New England Journal of Medicine · 2021 · 938 citations · Full text

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Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

Aline Uwimana, Eric Legrand, Barbara H. Stokes et al. · Nature Medicine · 2020 · 890 citations · Full text

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