Michael E. Chirgwin

Molecular Conformation of Bent-Core Molecules Affected by Chiral Side Chains Dictates Polymorphism and Chirality in Organic Nano- and Microfilaments

Jiao Liu, Sasan Shadpour, Marianne E. Prévôt et al. · ACS Nano · 2021 · 23 citations

Synthesis and activity of β-carboline antimalarials targeting the Plasmodium falciparum heat shock 90 protein

Neil K. Viswanathan, Michael E. Chirgwin, Julia Gibbs et al. · Bioorganic & Medicinal Chemistry Letters · 2023 · 16 citations · Full text

β-Carboline Antimalarials, Natural Product Harmine, Biochemistry +11

Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore

Han Wee Ong, Anna Truong, Frank E. Kwarcinski et al. · European Journal of Medicinal Chemistry · 2022 · 15 citations · Full text

Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome

Christopher R. Mansfield, Baiyi Quan, Michael E. Chirgwin et al. · Cell chemical biology · 2024 · 14 citations · Full text

Protein Function, Medicine, Natural Sciences +6

Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial <i>Pf</i> GSK3/ <i>Pf</i> PK6 with Activity against Blood Stage Parasites In Vitro

Kareem A. Galal, Anna Truong, Frank E. Kwarcinski et al. · Journal of Medicinal Chemistry · 2022 · 11 citations · Full text