Rainer Wilcken

Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology

Rainer Wilcken, Markus O. Zimmermann, Andreas Lange et al. · Journal of Medicinal Chemistry · 2012 · 1.3K citations · Full text

Pharmacy, Chemical Biology, Medicinal Chemistry +15

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

Rainer Wilcken, Xiangrui Liu, Markus O. Zimmermann et al. · Journal of the American Chemical Society · 2012 · 237 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +16

Small molecule induced reactivation of mutant p53 in cancer cells

Xiangrui Liu, Rainer Wilcken, Andreas C. Joerger et al. · Nucleic Acids Research · 2013 · 234 citations · Full text

Life Sciences, Molecular Biology, Oncology +14

Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency

Svjetlana Lovric, Sara Gonçalves, Heon Yung Gee et al. · Journal of Clinical Investigation · 2017 · 208 citations · Full text

Medicine, Genetics, Molecular Genetics +17

Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C

Andreas Weiss, Edwige Lorthiois, Louise Barys et al. · Cancer Discovery · 2022 · 134 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13