Rainer Wilcken

Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology

Rainer Wilcken, Markus O. Zimmermann, Andreas Lange et al. · Journal of Medicinal Chemistry · 2012 · 1.3K citations · Full text

Halogenation, Molecular Recognition, Medicinal Chemistry +15

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

Rainer Wilcken, Xiangrui Liu, Markus O. Zimmermann et al. · Journal of the American Chemical Society · 2012 · 229 citations · Full text

Molecular Biology, Chemical Biology, Mutant P53 +20

Small molecule induced reactivation of mutant p53 in cancer cells

Xiangrui Liu, Rainer Wilcken, Andreas C. Joerger et al. · Nucleic Acids Research · 2013 · 224 citations · Full text

Protein Assembly, Y220c Mutant, Molecular Biology +20

Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency

Svjetlana Lovric, Sara Gonçalves, Heon Yung Gee et al. · Journal of Clinical Investigation · 2017 · 205 citations · Full text

Genetics, Renal Pathology, Steroid-resistant Nephrotic Syndrome +17

Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C

Andreas Weiss, Edwige Lorthiois, Louise Barys et al. · Cancer Discovery · 2022 · 130 citations · Full text