Andreas C. Joerger

Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology

Rainer Wilcken, Markus O. Zimmermann, Andreas Lange et al. · Journal of Medicinal Chemistry · 2012 · 1.3K citations · Full text

Halogenation, Molecular Recognition, Medicinal Chemistry +15

Targeted rescue of a destabilized mutant of p53 by an <i>in silico</i> screened drug

Frank M. Boeckler, Andreas C. Joerger, Gaurav Jaggi et al. · Proceedings of the National Academy of Sciences · 2008 · 368 citations · Full text

Crystal Structure, Drug Target, Biomolecular Structure Prediction +18

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

Andreas C. Joerger, Hwee Ching Ang, Alan R. Fersht · Proceedings of the National Academy of Sciences · 2006 · 336 citations · Full text

Engineering, Molecular Biology, Tumor Biology +20

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

Rainer Wilcken, Xiangrui Liu, Markus O. Zimmermann et al. · Journal of the American Chemical Society · 2012 · 229 citations · Full text

Molecular Biology, Chemical Biology, Mutant P53 +20

Small molecule induced reactivation of mutant p53 in cancer cells

Xiangrui Liu, Rainer Wilcken, Andreas C. Joerger et al. · Nucleic Acids Research · 2013 · 224 citations · Full text

Protein Assembly, Y220c Mutant, Molecular Biology +20