Concepedia

METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma

Xiangyu Zeng, Fei Zhao, Gaofeng Cui, Yong Zhang, Rajashree A. Deshpande, Yuping Chen, Min Deng, Jake A. Kloeber, Yu Shi, Qin Zhou,

Nature Cancer · 2022 · 68 citations · 44 references

DOI

Concepts

References

44

Canonical sampling through velocity rescaling

Giovanni Bussi, Davide Donadio, Michele Parrinello · The Journal of Chemical Physics · 2007 · 18.4K citations · Full text

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Hannah Farmer, Nuala McCabe, Christopher J. Lord et al. · Nature · 2005 · 6.7K citations

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Helen E. Bryant, Niklas Schultz, Huw D. Thomas et al. · Nature · 2005 · 5.2K citations

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CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data

Jing Huang, Alexander D. MacKerell · Journal of Computational Chemistry · 2013 · 4.5K citations · Full text

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P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation

Berk Hess · Journal of Chemical Theory and Computation · 2007 · 4.1K citations

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