Concepedia

Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood–Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2

Xingui Liu, Alexia F. Kalogeropulou, Sofia Domingos, Nikolai Makukhin, Raja Sekhar Nirujogi, François Singh, Natalia Shpiro, Anton Saalfrank, Esther Sammler, Ian G. Ganley,

Journal of the American Chemical Society · 2022 · 172 citations · 65 references

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Abstract

and offer an attractive starting point for future drug development.

References

65

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

Jürgen Cox, Matthias Mann · Nature Biotechnology · 2008 · 15.7K citations

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The Perseus computational platform for comprehensive analysis of (prote)omics data

Stefka Tyanova, Tikira Temu, Pavel Sinitcyn et al. · Nature Methods · 2016 · 8.9K citations

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The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences

Yasset Pérez‐Riverol, Jingwen Bai, Chakradhar Bandla et al. · Nucleic Acids Research · 2021 · 6.7K citations · Full text

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Structural basis of PROTAC cooperative recognition for selective protein degradation

Morgan S. Gadd, Andrea Testa, Xavier Lucas et al. · Nature Chemical Biology · 2017 · 1.2K citations · Full text

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Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

Martin Steger, Francesca Tonelli, Genta Ito et al. · eLife · 2016 · 1.1K citations · Full text

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