Concepedia

Inhibitor Selectivity

Inhibitor Selectivity is a biochemical property that characterizes the preferential binding of an inhibitor to a specific enzyme or enzyme isoform over other structurally or functionally related enzymes, thereby distinguishing its action within a class of enzyme inhibitors.

1.8K

Publications

104K

Citations

9.8K

Authors

2.1K

Institutions

Publications per year

2017–2026

448

Parents

Publications

1.8K

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

David T. Dudley, Long Pang, Stuart J. Decker et al. · Proceedings of the National Academy of Sciences · 1995 · 2.7K citations · Full text

, , +15

A quantitative analysis of kinase inhibitor selectivity

Mazen W. Karaman, Sanna Herrgård, Daniel K. Treiber et al. · Nature Biotechnology · 2008 · 2.4K citations

, , +13

Comprehensive analysis of kinase inhibitor selectivity

Mindy I. Davis, Jeremy P. Hunt, Sanna Herrgård et al. · Nature Biotechnology · 2011 · 2.4K citations · Full text

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Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1

Masao Saitoh · The EMBO Journal · 1998 · 2.4K citations · Full text

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X-linked IAP is a direct inhibitor of cell-death proteases

Quinn L. Deveraux, Ryōsuke Takahashi, Guy S. Salvesen et al. · Nature · 1997 · 1.9K citations · Full text

, , +12

1–5 of 1.8K

Authors

9.8K

  1. DW
    David W. Christianson

    University of Pennsylvania, United States

    10 publications · 505 citations

    10

    h-index

  2. AH
    Akira Hara

    Gifu University, Japan

    10 publications · 211 citations

    10

    h-index

  3. GR
    George R. Stark

    Cleveland Clinic, United States

    8 publications · 1.2K citations

    8

    h-index

  4. MI
    Md. Imtaiyaz Hassan

    Jamia Millia Islamia, India

    8 publications · 562 citations

    8

    h-index

  5. SK
    Stefan Knapp

    University of Oxford, United Kingdom

    7 publications · 482 citations

    7

    h-index

1–5 of 9.8K

Institutions

2.1K

  1. Centre National de la Recherche Scientifique

    Paris, France

    25 h-index

    197 publications

    7.9K citations

  2. Scripps Research Institute

    San Diego, United States

    20 h-index

    96 publications

    8.1K citations

  3. Inserm

    Paris, France

    20 h-index

    106 publications

    4.5K citations

  4. Harvard University

    Cambridge, United States

    19 h-index

    95 publications

    6.2K citations

  5. University of Pennsylvania

    Philadelphia, United States

    18 h-index

    72 publications

    6.8K citations

  6. University of Leeds

    Leeds, United Kingdom

    17 h-index

    70 publications

    3.3K citations

  7. University of Michigan

    Ann Arbor, United States

    17 h-index

    83 publications

    5.8K citations

  8. University of Oxford

    Oxford, United Kingdom

    17 h-index

    91 publications

    5K citations

1–8 of 2.1K

Venues

  1. Journal of Biological Chemistry

    JBC · 106 publications · 10.2K citations

    58

    h-index

  2. Journal of Medicinal Chemistry

    132 publications · 9.6K citations

    54

    h-index

  3. Biochemistry

    101 publications · 5.4K citations

    44

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 33 publications · 8.2K citations

    31

    h-index

  5. Biochemical Journal

    BJ · 42 publications · 2.1K citations

    26

    h-index

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