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Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis

Anthony T. Ginnetti, Daniel V. Paone, Kausik K. Nanda, Jing Li, Marina Busuek, Scott Allen Johnson, Jun Lü, S.M. Soisson, R. Robinson, John W. Fisher,

Bioorganic & Medicinal Chemistry Letters · 2022 · 10 citations · 9 references

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References

9

The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases

Patrick Garnero, Olivier Borel, I. Byrjalsen et al. · Journal of Biological Chemistry · 1998 · 641 citations · Full text

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Effect of the Cathepsin K Inhibitor Odanacatib on Bone Resorption Biomarkers in Healthy Postmenopausal Women: Two Double-Blind, Randomized, Placebo-Controlled Phase I Studies

S. Aubrey Stoch, Stefan Zajic, Julie A. Stone et al. · Clinical Pharmacology & Therapeutics · 2009 · 156 citations

, , +17

Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis

Tadashi Hayami, Ya Zhuo, Gregg Wesolowski et al. · Bone · 2012 · 124 citations

, , +17

Up regulation of cathepsin K expression in articular chondrocytes in a transgenic mouse model for osteoarthritis

Jukka Morko · Annals of the Rheumatic Diseases · 2004 · 91 citations · Full text

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Murine Cathepsin F Deficiency Causes Neuronal Lipofuscinosis and Late-Onset Neurological Disease

Chi‐Hui Tang, Je–Wook Lee, Michael G. Galvez et al. · Molecular and Cellular Biology · 2006 · 80 citations · Full text

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