Gregg Wesolowski

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation <i>in vitro</i>

John Fisher, Michael J. Rogers, J. M. Halasy et al. · Proceedings of the National Academy of Sciences · 1999 · 679 citations

Medicine, Biochemistry, Pharmacology +17

Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis

Tadashi Hayami, Maureen Pickarski, Ya Zhuo et al. · Bone · 2005 · 627 citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +17

Characterization of a human osteosarcoma cell line (Saos-2) with osteoblastic properties.

Sevgi B. Rodan, Yasuo Imai, Mark A. Thiede et al. · PubMed · 1987 · 594 citations

Medicine, Cell Biology, Bone Metabolism +14

The role of subchondral bone remodeling in osteoarthritis: Reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model

Tadashi Hayami, Maureen Pickarski, Gregg Wesolowski et al. · Arthritis & Rheumatism · 2004 · 560 citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +17

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

Jacques Yves Gauthier, Nathalie Chauret, Wanda Cromlish et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 473 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10