The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

Paul Säftig, Ernst B. Hunziker, Olaf Wehmeyer et al. · Proceedings of the National Academy of Sciences · 1998 · 910 citations

Medicine, Cell Biology, Molecular Biology +17

Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus

T Nakagawa, Wera Roth, Phillip Wong et al. · Science · 1998 · 662 citations

Life Sciences, Cell Biology, Immunology +17

A novel chromium trioxide catalyzed oxidation of primary alcohols to the carboxylic acids

Mangzhu Zhao, Jing Li, Zhiguo J. Song et al. · Tetrahedron Letters · 1998 · 221 citations

Natural Sciences, Chemical Engineering, Chemistry +14

Lysosomotropism of Basic Cathepsin K Inhibitors Contributes to Increased Cellular Potencies against Off-Target Cathepsins and Reduced Functional Selectivity

Jean‐Pierre Falgueyret, Sylvie Desmarais, Renata M. Oballa et al. · Journal of Medicinal Chemistry · 2005 · 153 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K

W. Cameron Black, Christopher I. Bayly, Dana Davis et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 140 citations

Life Sciences, Chemistry, Medicinal Chemistry +14