Dimethyl itaconate reprograms neurotoxic to neuroprotective primary astrocytes through the regulation of NLRP3 inflammasome and NRF2/HO-1 pathways

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Neurotoxic reactive astrocytes are induced by activated microglia

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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

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Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

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Life Sciences, Immunology, Molecular Biology +17