Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells - Concepedia

Concepedia

Publication | Open Access

Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells

DOI Full Paper Access

57

Citations

57

References

2022

Year

Mareike Berlak, Elizabeth R. Tucker, Mathurin Dorel, Annika Winkler, Aleixandria McGearey, Elias Rodríguez-Fos, Barbara Martins Da Costa, Karen Barker, Elicia Fyle, Elizabeth Calton,

Molecular Cancer

Abstract

Our results provide a clinically relevant mechanistic model of ALKi resistance in neuroblastoma and highlight new clinically actionable collateral sensitivities in resistant cells.

References

	Year	Citations

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