Concepedia

Nras Mutation

NRAS Mutation is a somatic point mutation in the NRAS proto-oncogene, predominantly occurring at codon 61, that constitutively activates the MAPK signaling pathway, leading to uncontrolled melanocyte proliferation and contributing to the pathogenesis of malignant melanocytic tumors.

781

Publications

59K

Citations

6.7K

Authors

1.6K

Institutions

Publications per year

2017–2026

338

Parents

Publications

781

Somatic Activation of KIT in Distinct Subtypes of Melanoma

John A. Curtin, Klaus J. Busam, Daniel Pinkel et al. · Journal of Clinical Oncology · 2006 · 1.6K citations · Full text

, , +17

Colon Cancer, Version 1.2017, NCCN Clinical Practice Guidelines in Oncology

Al B. Benson, Alan P. Venook, Lynette Cederquist et al. · Journal of the National Comprehensive Cancer Network · 2017 · 1.4K citations · Full text

, , +17

The Genetic Evolution of Melanoma from Precursor Lesions

A. Hunter Shain, Iwei Yeh, Ivanka Kovalyshyn et al. · New England Journal of Medicine · 2015 · 1.1K citations · Full text

, , +17

Fluorouracil, Leucovorin, and Irinotecan Plus Cetuximab Treatment and <i>RAS</i> Mutations in Colorectal Cancer

Eric Van Cutsem, Heinz‐Josef Lenz, Claus-Henning Köhne et al. · Journal of Clinical Oncology · 2015 · 800 citations · Full text

, , +17

<i>NRAS</i> mutation status is an independent prognostic factor in metastatic melanoma

John Jakob, Roland L. Bassett, Chaan S. Ng et al. · Cancer · 2011 · 690 citations · Full text

, , +17

1–5 of 781

Authors

6.7K

  1. RD
    Reinhard Dummer

    University Hospital of Zurich, Switzerland

    20 publications · 3.5K citations

    18

    h-index

  2. PA
    Paolo A. Ascierto

    Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Italy

    18 publications · 2.3K citations

    16

    h-index

  3. DS
    Dirk Schadendorf

    Heidelberg University, Germany

    17 publications · 2.4K citations

    16

    h-index

  4. MA
    Michael A. Davies

    The University of Texas MD Anderson Cancer Center, United States

    15 publications · 1.9K citations

    15

    h-index

  5. RA
    Richard A. Scolyer

    Royal Prince Alfred Hospital, Australia

    14 publications · 2.1K citations

    14

    h-index

1–5 of 6.7K

Institutions

1.6K

  1. The University of Texas MD Anderson Cancer Center

    Houston, United States

    34 h-index

    275 publications

    34.8K citations

  2. Memorial Sloan Kettering Cancer Center

    New York, United States

    32 h-index

    238 publications

    36.3K citations

  3. University of California, San Francisco

    San Francisco, United States

    28 h-index

    189 publications

    29.4K citations

  4. Massachusetts General Hospital

    Boston, United States

    26 h-index

    112 publications

    12.7K citations

  5. Harvard University

    Cambridge, United States

    26 h-index

    122 publications

    13.5K citations

  6. Dana-Farber Cancer Institute

    Boston, United States

    22 h-index

    110 publications

    12.2K citations

  7. Inserm

    Paris, France

    21 h-index

    115 publications

    5.5K citations

  8. The University of Sydney

    Sydney, Australia

    21 h-index

    157 publications

    23.2K citations

1–8 of 1.6K

Venues

  1. Clinical Cancer Research

    32 publications · 4.1K citations

    30

    h-index

  2. Journal of Investigative Dermatology

    JID · 27 publications · 3K citations

    22

    h-index

  3. Oncotarget

    24 publications · 1.5K citations

    20

    h-index

  4. Journal of Clinical Oncology

    30 publications · 5K citations

    20

    h-index

  5. Pigment Cell & Melanoma Research

    23 publications · 1.4K citations

    20

    h-index

1–5