Concepedia

DNA Topoisomerase Inhibitor Acutissimin A and Other Flavano‐Ellagitannins in Red Wine

Stéphane Quideau, Michaël Jourdes, Cédric Saucier, Yves Glories, Patrick Pardon, Christian Baudry

Angewandte Chemie · 2003 · 16 citations · 10 references

DOI

Concepts

Abstract

Zum Wohl! Acutissimin A und andere Flavano-Ellagitannine entstehen beim Ausbau von Wein in Eichenholzfässern durch diastereoselektive nichtenzymatische Kondensationsreaktionen zwischen Flavan-3-olen aus den Trauben und dem Ellagitannin Vescalagin aus dem Eichenholz. Acutissimin A ist in vitro ein 250-mal stärkerer DNA-Topoisomerase-Inhibitor als das klinisch verwendete Tumortherapeutikum Etoposid.

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