David R. Spring

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

Warren R. J. D. Galloway, Albert Isidro‐Llobet, David R. Spring · Nature Communications · 2010 · 869 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +14

Zn²⁺-Triggered Amide Tautomerization Produces a Highly Zn²⁺-Selective, Cell-Permeable, and Ratiometric Fluorescent Sensor

Zhaochao Xu, Kyung-Hwa Baek, Hana Kim et al. · Journal of the American Chemical Society · 2009 · 690 citations

Natural Sciences, Chemistry, Materials Science +17

Diversity-oriented synthesis; a challenge for synthetic chemistsElectronic supplementary information (ESI) available: Excel file of all the FDA new molecular entities between the years 1998 and July 2003, and new drug approvals between the years 1990 and 2002. See http://www.rsc.org/suppdata/ob/b3/b310752n/

David R. Spring · Organic & Biomolecular Chemistry · 2003 · 337 citations

Pharmacy, Chemistry, Medicinal Chemistry +6

A Lysosome-Targetable Fluorescent Probe for Imaging Hydrogen Sulfide in Living Cells

Tianyu Liu, Zhaochao Xu, David R. Spring et al. · Organic Letters · 2013 · 287 citations

Natural Sciences, Biochemistry, Chemistry +17

Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips

Jing Huang, Heng Zhu, Stephen J. Haggarty et al. · Proceedings of the National Academy of Sciences · 2004 · 246 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17