Peptide-based long-acting co-agonists of GLP-1 and cholecystokinin 1 receptors as novel anti-diabesity agents

Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide

Jesper Lau, Paw Bloch, Lauge Schäffer et al. · Journal of Medicinal Chemistry · 2015 · 959 citations · Full text

Albumin Affinity, Glycobiology, Peptide Science +19

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

Jonathan W. Day, Nickki Ottaway, James T Patterson et al. · Nature Chemical Biology · 2009 · 617 citations · Full text

Obesity, Metabolic Syndrome, Energy Homeostasis +12

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

Brian Finan, Bin Yang, Nickki Ottaway et al. · Nature Medicine · 2014 · 609 citations · Full text

Obesity, Metabolic Syndrome, Neuropeptides +11

Glucagon-like Peptide-1 (GLP-1) Analogs: Recent Advances, New Possibilities, and Therapeutic Implications

Bikash Manandhar, Jung‐Mo Ahn · Journal of Medicinal Chemistry · 2014 · 188 citations

Glp-1 Analogs, Peptide Science, Peptide Therapeutics +21

Design of Novel Exendin-Based Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists

Andreas Evers, Torsten Haack, M. Lorenz et al. · Journal of Medicinal Chemistry · 2017 · 98 citations · Full text

Biochemistry, Functional Selectivity, Medicine +14