Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036

Wayne W. Chan, Scott Wise, Michael D. Kaufman, +24

Cancer Cell

Switch-control Inhibitor Dcc-2036Signal TransductionSignaling PathwayConformational Control InhibitionCell Regulation +7

A novel dual glucagon‐like peptide and glucagon receptor agonist SAR425899: Results of randomized, placebo‐controlled first‐in‐human and first‐in‐patient trials

J. Tillner, Maximilian Posch, Frank Wagner, +8

Diabetes Obesity and Metabolism

Design of Novel Exendin-Based Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists

Andreas Evers, Torsten Haack, M. Lorenz, +10

Journal of Medicinal Chemistry

BiochemistryFunctional SelectivityMedicineDrug DiscoveryPeptide Library +12

Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations

Andreas Evers, Martin Bossart, Stefania Pfeiffer‐Marek, +13

Journal of Medicinal Chemistry

Peptide EngineeringGlycobiologyPharmacotherapyMultidose FormulationsMedicinal Chemistry +14

Receptor occupancy of dual glucagon-like peptide 1/glucagon receptor agonist SAR425899 in individuals with type 2 diabetes

Olof Eriksson, Torsten Haack, Youssef Hijazi, +10

Scientific Reports

Running on mixed fuel‐dual agonistic approach of GLP‐1 and GCG receptors leads to beneficial impact on body weight and blood glucose control: A comparative study between mice and non‐human primates

Ralf Elvert, Andreas W. Herling, Martin Bossart, +13

Diabetes Obesity and Metabolism

Incretin combination therapy for the treatment of non‐alcoholic steatohepatitis

Aimo Kannt, Andreas Nygaard Madsen, Claire Kammermeier, +14

Diabetes Obesity and Metabolism

Synthesis of a quinolone library from ynones

Timothy R. Ward, Brandon J. Turunen, Torsten Haack, +3

Tetrahedron Letters

PharmacologySynthetic ChemistryQuinolone LibraryNatural Product Synthesis

Mutagenicity in Salmonella typhimurium TA98 and TA100 of nitroso and respective hydroxylamine compounds

Torsten Haack, Lothar Erdinger, Gernot Boche

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

BiochemistryReactive Nitrogen SpecieNitrosative StressSalmonella Typhimurium Ta98Toxicology +5

From mutagenic to non-mutagenic nitroarenes: effect of bulky alkyl substituents on the mutagenic activity of 4-nitrobiphenyl in Salmonella typhimurium

Markus Klein, Ulrike Voigtmann, Torsten Haack, +2

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

BiochemistryNon-mutagenic NitroarenesReactive Nitrogen SpecieNitrosative StressSalmonella Typhimurium +5