Journal of Agricultural and Food Chemistry · 2022 · 43 citations · 20 references
Life SciencesCell BiologyNeuroscienceAutophagyMitochondrial BiologyNeurodegenerationAntioxidant DefenseMitochondrial BioenergeticsMitochondrial DysfunctionMitochondrial PhysiologyMitophagyOxidative StressAntioxidant PeptidesGlutathione Peroxidase ActivityMitochondrial Oxidative StressMitophagy EnhancementOxidative Stress InjuryOxidative Stress RegulationOxidative Stress-induced AutophagySuperoxide Dismutase Function
, caspase-9, and cleaved-caspase-3 expression. Additionally, BDNF and SNAP-25 levels significantly increased to protect the synaptic function. Collectively, TW-7 improved oxidative stress-mediated nerve cell injury via JNK-regulated PINK1-mediated mitophagy.
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