PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer’s disease

Fang Du, Qing Yu, Shijun Yan, +7

Brain

Mitochondrial DysfunctionMolecular BiologyAlzheimer ’Synaptic SignalingOxidative Stress +16

Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease

Shijun Yan, Cheng Jiang, Annette Janzen, +7

JAMA Neurology

Mfn2 is Required for Mitochondrial Development and Synapse Formation in Human Induced Pluripotent Stem Cells/hiPSC Derived Cortical Neurons

Fang Du, Shijun Yan, Qing Yu, +2

Scientific Reports

Multi-faced neuroprotective effects of geniposide depending on the RAGE-mediated signaling in an Alzheimer mouse model

Cui Lv, Lei Wang, Xiaoli Liu, +4

Neuropharmacology

Alzheimer's DiseaseAlzheimer Mouse ModelMedicinePharmacologyMulti-faced Neuroprotective Effects +11

(+)‐Catechin ameliorates diabetic nephropathy by trapping methylglyoxal in type 2 diabetic mice

Dina Zhu, Lei Wang, Qi‐Le Zhou, +4

Molecular Nutrition & Food Research

Increased neuronal PreP activity reduces Aβ accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse model

Fang Du, Yongfu Wang, Zhihua Zhang, +16

Human Molecular Genetics

Synaptic TransmissionSynaptic SignalingSynaptic FunctionOxidative StressMitochondrial Oxidative Stress +22

Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer’s disease

Peter Koppensteiner, Fabrizio Trinchese, Mauro Fà, +12

Scientific Reports

Identification of a Novel 1,2,3,4-Tetrahydrobenzo[<i>b</i>][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer’s Disease

Jole Fiorito, Jérémie Vendôme, Faisal Saeed, +6

Journal of Medicinal Chemistry

PP2A methylation controls sensitivity and resistance to β-amyloid–induced cognitive and electrophysiological impairments

Russell E. Nicholls, Jean‐Marie Sontag, Hong Zhang, +12

Proceedings of the National Academy of Sciences

Neurodegenerative DiseasesAlzheimer's DiseaseElevated LevelsBiochemistryβ-Amyloid Peptide +12

Overexpression of endophilin A1 exacerbates synaptic alterations in a mouse model of Alzheimer’s disease

Qing Yu, Yongfu Wang, Fang Du, +10

Nature Communications