iScience · 2021 · 33 citations · 52 references
Life SciencesNeurobiologyNeuroscienceCellular NeuroscienceMolecular NeuroscienceNeurodegenerationAlzheimer DiseaseNeural Stem CellsNeurodegenerative DiseasesNeurodegenerative DisordersProtein AggregationTau PathologyAlzheimer Disease Tau PathologyHuman Cell-based In Vitro ModelsHuman Induced Pluripotent Stem Cell ModelsMolecular TemplatingTau AggregationTau Protein AggregationTau SeedingTauopathy Models
model presented here represents the first successful demonstration of combining human neurons, endogenous tau expression, and AD brain-derived competent tau species, offering a more physiologically relevant platform to study tau pathobiology.
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Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong, F. Ann Ran, David Cox et al. · Science · 2013 · 15.7K citations
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
Maj-Linda B. Selenica, Milene L. Brownlow, Jeffy P. Jimenez et al. · Neurodegenerative Diseases · 2012 · 10.4K citations · Full text
RNA-Guided Human Genome Engineering via Cas9
Prashant Mali, Luhan Yang, Kevin M. Esvelt et al. · Science · 2013 · 9.4K citations · Full text
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
Mike Hutton, Corinne Lendon, Patrizia Rizzu et al. · Nature · 1998 · 3.5K citations
Life Sciences, Genetics, Neurology +14