Concepedia
Hepatology · 2021 · 36 citations · 38 references
FXR plays a pivotal role in regulating iron homeostasis and protects mice against iron hepatotoxicity. Targeting FXR may represent a therapeutic strategy for IO-associated chronic liver diseases.
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Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist
Sama I. Sayin, Annika Wahlström, Jenny Felin et al. · Cell Metabolism · 2013 · 2.2K citations · Full text
Dysbiosis, Biochemistry, Biliary Tract +9
A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis
Bryan Goodwin, Stacey A. Jones, Roger R. Price et al. · Molecular Cell · 2000 · 1.9K citations · Full text
Signal Transduction, Biochemistry, Biliary Tract +10
Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
Christopher J. Sinal, Masahiro Tohkin, Masaaki Miyata et al. · Cell · 2000 · 1.8K citations · Full text
Signal Transduction, Oxysterol, Biochemistry +7
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
Takeshi Inagaki, Mihwa Choi, Antonio Moschetta et al. · Cell Metabolism · 2005 · 1.8K citations · Full text
Bile Acid Homeostasis, Developmental Biology, Biliary Tract +9
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
Sungsoon Fang, Jae Myoung Suh, Shannon M. Reilly et al. · Nature Medicine · 2015 · 697 citations · Full text
Obesity, Metabolic Syndrome, Insulin Resistance +12