Science Advances · 2021 · 91 citations · 64 references
MedicineOncologyPharmacologyCancer PharmacologyMolecular OncologyNeoplasiaAntioxidant DefenseCancer Cell SignalingCancer MetabolismMetabolic ReprogrammingMetabolic Reprogramming In CancerReactive Oxygen SpeciesAnticancer ActivityNrf2 Pathway ActivationNrf2 Signaling PathwayNrf2-mediated Cytoprotective SignalingNrf2-mediated ResponsesOxidative Stress In CancerRedox Metabolism In CancerTumor Metabolism
mutant tumor growth, and this suppression was further augmented by TCA depletion by glutaminase inhibition. Thus, G6PD inhibition–induced TCA depletion is a therapeutic vulnerability of NRF2-activated cancer.
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QuPath: Open source software for digital pathology image analysis
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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
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