Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

Rodrigo Romero, Volkan I. Sayin, Shawn M. Davidson, +25

Nature Medicine

Tumor BiologyMedicineKras-driven Lung CancerCancer GenomicsBronchial Neoplasm +9

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

Luca Lignitto, Sarah E. LeBoeuf, Harrison Homer, +10

Cell

Tumor BiologyOncogenic AgentMedicineCancer BiologyTumor Suppressor +5

Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression

Antonio F. Santidrián, Akemi Matsuno‐Yagi, Melissa Ritland, +5

Journal of Clinical Investigation

Nad+/nadh BalanceBreast OncologyMitochondrial FunctionBiochemistryMedicine +9

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

Volkan I. Sayin, Sarah E. LeBoeuf, Simranjit X. Singh, +15

eLife

Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids

Sarah E. LeBoeuf, Warren Wu, Triantafyllia Karakousi, +7

Cell Metabolism

Reductive StressBiochemistryMedicineLipid PeroxidationOxidative Stress Response +6

RFX2 is broadly required for ciliogenesis during vertebrate development

Mei-I Chung, Sara M. Peyrot, Sarah E. LeBoeuf, +4

Developmental Biology

Vertebrate DevelopmentDevelopmental BiologyMorphogenesisEmbryonic DevelopmentCell Fate Determination +2

Discrimination of flavonoids and red wine varietals by arrays of differential peptidic sensors

Alona P. Umali, Sarah E. LeBoeuf, Robert W. Newberry, +9

Chemical Science

EngineeringFlavoromicsFood AnalysisDifferential Sensor ArraysPolyphenolics +17

Measuring Food Intake and Nutrient Absorption in <i>Caenorhabditis elegans</i>

Rafael L Gomez-Amaro, Elizabeth R. Valentine, Maria Carretero, +6

Genetics

Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition

Hongyu Ding, Zihong Chen, Katherine Wu, +6

Science Advances

Valine tRNA levels and availability regulate complex I assembly in leukaemia

Palaniraja Thandapani, Andreas Kloetgen, Matthew T. Witkowski, +9

Nature

Hematological MalignancyChromatinSystems BiologyEngineeringMixed-phenotype Acute Leukemia +7