Concepedia

Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition

Carien Dekker, Henri Mattes, Michael Wright, Andreas Boettcher, Alexandra Hinniger, Nicola Hughes, Sandra Kapps-Fouthier, Jörg Eder, P. Erbel, Nikolaus Stiefl,

Journal of Molecular Biology · 2021 · 160 citations · 30 references

Concepts

Life SciencesBiochemistryMolecular BiologyInnate ImmunitySignal TransductionStructural BiologyInflammasome ActivationInflammatory SignalingNod-like ReceptorsProtein StructureStructural DomainsStructural MotifsInflammasome Assembly MechanismsInflammasome Inhibition MechanismsInflammasome ModulationInflammasome RegulationInhibitor SelectivityNlr Family Pyrin Domain-containing 3 InflammasomeNlrp3 Inflammasome

References

30

Features and development of <i>Coot</i>

Paul Emsley, Bernhard Lohkamp, W. G. Scott et al. · Acta Crystallographica Section D Biological Crystallography · 2010 · 29.6K citations · Full text

Natural Sciences, Chemistry, Biomolecular Modeling +16

<i>Phaser</i>crystallographic software

Airlie J. McCoy, Ralf W. Grosse‐Kunstleve, Paul D. Adams et al. · Journal of Applied Crystallography · 2007 · 20.9K citations · Full text

Natural Sciences, Chemistry, Computational Chemistry +16

Wolfgang Kabsch · Acta Crystallographica Section D Biological Crystallography · 2010 · 16.9K citations · Full text

Computing, Computer Science, Computational Geometry +13

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in <i>Phenix</i>

Dorothée Liebschner, Pavel V. Afonine, Matthew L. Baker et al. · Acta Crystallographica Section D Structural Biology · 2019 · 7.4K citations · Full text

Life Sciences, Biophysics, Computational Chemistry +16

Gout-associated uric acid crystals activate the NALP3 inflammasome

Fabio Martinon, Virginie Pétrilli, Annick Mayor et al. · Nature · 2006 · 5.2K citations

Life Sciences, Cell Biology, Immunology +11