Andreas Boettcher

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive <scp>NLRP</scp> 3 inflammasome assembly

Kaiwen Chen, Benjamin Demarco, Rosalie Heilig et al. · The EMBO Journal · 2019 · 375 citations · Full text

Inflammation, Signal Transduction, Signaling Pathway +12

Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition

Carien Dekker, Henri Mattes, Michael Wright et al. · Journal of Molecular Biology · 2021 · 149 citations

Crystal Structure, Anti-inflammatory, Signal Transduction +9

Clonal Hematopoiesis of Indeterminate Potential With Loss of <i>Tet2</i> Enhances Risk for Atrial Fibrillation Through <i>Nlrp3</i> Inflammasome Activation

Amy E. Lin, Aneesh Bapat, Ling Xiao et al. · Circulation · 2024 · 65 citations · Full text

Fragment-Based Screening by Biochemical Assays: Systematic Feasibility Studies with Trypsin and MMP12

Andreas Boettcher, Simon Ruedisser, P. Erbel et al. · SLAS DISCOVERY · 2010 · 40 citations · Full text

Engineering, Biological Mass Spectrometry, Peptide Science +24

Readout Technologies for Highly Miniaturized Kinase Assays Applicable to High-Throughput Screening in a 1536-Well Format

Martin Klumpp, Andreas Boettcher, Damaris Becker et al. · SLAS DISCOVERY · 2006 · 40 citations · Full text