Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps

Kaiwen Chen, Mercedes Monteleone, Dave Boucher, +7

Science Immunology

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

Dave Boucher, Mercedes Monteleone, Rebecca C. Coll, +10

The Journal of Experimental Medicine

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

Stephanie A. Conos, Kaiwen Chen, Dominic De Nardo, +10

Proceedings of the National Academy of Sciences

ApoptosisImmunologyImmune RegulationCell DeathInnate Immunity +24

The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge

Kaiwen Chen, Christina J. Groß, Flor Vásquez Sotomayor, +4

Cell Reports

Microbial PathogensInnate Immune SystemImmunologyImmune RegulationAcute Salmonella Challenge +19

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive <scp>NLRP</scp> 3 inflammasome assembly

Kaiwen Chen, Benjamin Demarco, Rosalie Heilig, +5

The EMBO Journal

InflammationSignal TransductionSignaling PathwayMedicineApoptosis +10

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

Mercedes Monteleone, Amanda C. Stanley, Kaiwen Chen, +11

Cell Reports

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

José Carlos Santos, Dave Boucher, Larisa E. Kapinos, +7

Nature Communications

Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

Benjamin Demarco, James P. Grayczyk, Elisabet Bjånes, +11

Science Advances

ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome

Kim S. Robinson, Gee Ann Toh, Pritisha Rozario, +24

Science

XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation

Kate E. Lawlor, Rebecca Feltham, Monica Yabal, +16

Cell Reports