Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer's disease

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

Salvatore Oddo, Antonella Caccamo, Jason D. Shepherd et al. · Neuron · 2003 · 4.1K citations · Full text

Alzheimer's Disease, Dementia, Degenerative Disease +5

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Brinda Ravikumar, Zdenek Berger, J. Eric Davies et al. · Nature Genetics · 2004 · 2.3K citations · Full text

Cell Autophagy, Mitophagy, Medicine +9

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

Mario Mauthe, Idil Orhon, Cecilia Rocchi et al. · Autophagy · 2018 · 2K citations · Full text

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Lennart Mucke, Eliezer Masliah, Gui-Qiu Yu et al. · Journal of Neuroscience · 2000 · 1.9K citations · Full text

Neurodegenerative Diseases, Molecular Neuroscience, Alzheimer's Disease +15

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

José A. Martina, Yong Chen, Marjan Guček et al. · Autophagy · 2012 · 1.3K citations · Full text

Mitophagy, Molecular Biology, Autophagy Genes +18