J. Eric Davies

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Brinda Ravikumar, Zdenek Berger, J. Eric Davies et al. · Nature Genetics · 2004 · 2.3K citations · Full text

Cell Autophagy, Mitophagy, Medicine +9

Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and α-Synuclein

Sovan Sarkar, J. Eric Davies, Zebo Huang et al. · Journal of Biological Chemistry · 2006 · 1.1K citations · Full text

Mitophagy, Molecular Biology, Cell Death +18

Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy

J. Eric Davies, Sovan Sarkar, David C. Rubinsztein · Human Molecular Genetics · 2005 · 203 citations

Molecular Biology, Cytoskeleton, Skeletal Muscle Nuclei +17

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases

Shouqing Luo, J. Eric Davies, David C. Rubinsztein · The Journal of Cell Biology · 2005 · 192 citations · Full text

Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice

J. Eric Davies, Lin Wang, Lourdes Garcia-Oroz et al. · Nature Medicine · 2005 · 152 citations

Doxycycline Attenuates, Delays Toxicity, Medicine +3