Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Heather R. Christofk, Matthew G. Vander Heiden, Marian H. Harris et al. · Nature · 2008 · 2.8K citations

Tumor Biology, Medicine, Molecular Biology +9

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

Larry Gold, Deborah Ayers, Jennifer Bertino et al. · PLoS ONE · 2010 · 1.7K citations · Full text

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Dimitrios Anastasiou, George Poulogiannis, John M. Asara et al. · Science · 2011 · 1.2K citations · Full text

Lipid Peroxidation, Cell Death, Metabolic Remodeling +19

Pyruvate kinase M2 is a phosphotyrosine-binding protein

Heather R. Christofk, Matthew G. Vander Heiden, Ning Wu et al. · Nature · 2008 · 999 citations

Pyruvate Kinase M2, Signal Transduction, Biochemistry +6

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Dimitrios Anastasiou, Yimin Yu, William J. Israelsen et al. · Nature Chemical Biology · 2012 · 804 citations · Full text