Concepedia

Pyruvate kinase M2 is a phosphotyrosine-binding protein

Heather R. Christofk, Matthew G. Vander Heiden, Ning Wu, John M. Asara, Lewis C. Cantley

Nature · 2008 · 1K citations · 16 references

DOI

Concepts

References

16

On the Origin of Cancer Cells

Otto Warbürg · Science · 1956 · 13.3K citations

, , +12

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Heather R. Christofk, Matthew G. Vander Heiden, Marian H. Harris et al. · Nature · 2008 · 2.8K citations

, , +16

ATP citrate lyase inhibition can suppress tumor cell growth

Georgia Hatzivassiliou, Fangping Zhao, Daniel E. Bauer et al. · Cancer Cell · 2005 · 1.1K citations · Full text

, , +14

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

Pradip K. Majumder, Phillip G. Febbo, Rachel Bikoff et al. · Nature Medicine · 2004 · 956 citations

, , +15

A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC)

Shao‐En Ong, Matthias Mann · Nature Protocols · 2006 · 899 citations

, , +15