An in vitro study shows the potential of Nostoc commune (Cyanobacteria) polysaccharides extract for wound-healing and anti-allergic use in the cosmetics industry

Abstract

Nostoc commune has abundant bioactive compounds, which are valuable in medical, cosmeceutical, and nutraceutical fields. Currently, the demand for native bioactive compounds in the cosmetic industry is greater than ever, especially with regard to algae extracts. In this study, we evaluated the biochemical compounds, safety, and effect on wound-healing and anti-allergic properties of Nostoc commune polysaccharide-rich extract (NCPE) in an in vitro study. The results showed that an extract with 221.69 ± 25.56 mg g−1 polysaccharide mainly consists of glucose (73.2%) with abundant bioactive compounds (total phenolic, total flavonoids, and sulfates) and some elements (K, Sr, Mn, Ba, and Ni). Cytotoxicity and heavy metal assays revealed that the extract was safe and available. Cell culture experiments showed that the polysaccharide effectively inhibits IL-6, and β-hexosaminidase, but promotes collagen I secretion. These findings suggest that the extract may be a useful resource in the development of wound-healing and anti-allergic cosmetics.