Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice

Disruption of IRS-2 causes type 2 diabetes in mice

Dominic J. Withers, Julio Sanchez Gutierrez, Heather Towery et al. · Nature · 1998 · 1.8K citations

Metabolic Syndrome, Medicine, Diabetes +5

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

Rohit Kulkarni, Jens C. Brüning, Jonathon N. Winnay et al. · Cell · 1999 · 1.1K citations · Full text

Insulin Resistance, Insulin Signaling, Molecular Physiology +13

Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

Pedro L. Herrera · Development · 2000 · 661 citations

Genetics, Cell Specialization, Cellular Physiology +17

Lower blood glucose, hyperglucagonemia, and pancreatic α cell hyperplasia in glucagon receptor knockout mice

Richard W. Gelling, Xiaoqing Du, Darwin S. Dichmann et al. · Proceedings of the National Academy of Sciences · 2003 · 552 citations · Full text

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

Naoto Kubota, Kazuyuki Tobe, Yasuo Terauchi et al. · Diabetes · 2000 · 524 citations · Full text

Insulin Receptor, Insulin Signaling, Causes Type 2 +20