Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

Handbook of Physiology.

F. Plum · Archives of Neurology · 1960 · 10.4K citations

Life Sciences, Physiology, Electrophysiology +10

Inducible Gene Targeting in Mice

Ralf Kühn, Frieder Schwenk, Michel Aguet et al. · Science · 1995 · 1.9K citations · Full text

Life Sciences, Genetics, Molecular Genetics +14

Disruption of IRS-2 causes type 2 diabetes in mice

Dominic J. Withers, Julio Sanchez Gutierrez, Heather Towery et al. · Nature · 1998 · 1.8K citations

Life Sciences, Endocrinology, Molecular Biology +12

Insulin Resistance and Insulin Secretory Dysfunction as Precursors of Non-Insulin-Dependent Diabetes Mellitus: Prospective Studies of Pima Indians

Stephen Lillioja, David M. Mott, Maximilian Spraul et al. · New England Journal of Medicine · 1993 · 1.5K citations · Full text

Medicine, Endocrinology, Diabetology +14

Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting

Hua Gu, Jamey D. Marth, Paul C. Orban et al. · Science · 1994 · 1.4K citations

Life Sciences, Genetics, Molecular Genetics +17