Concepedia

Tissue-specific Knockout Models

Tissue-Specific Knockout Models is a type of genetically engineered animal model in which the inactivation of a target gene is restricted to a specific tissue or cell type, allowing for the study of gene function in a spatially controlled manner while avoiding systemic effects.

96

Publications

8.3K

Citations

756

Authors

269

Institutions

Publications per year

2017–2026

38

Variants

Conditional Knockout Models

Parents

Publications

96

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

Rohit Kulkarni, Jens C. Brüning, Jonathon N. Winnay et al. · Cell · 1999 · 1.2K citations · Full text

, , +17

Animal models in type 2 diabetes research: an overview.

K. K. Srinivasan, Poduri Ramarao · PubMed · 2007 · 724 citations

, , +17

Angiopoietin-1 is essential in mouse vasculature during development and in response to injury

Marie Jeansson, Alexander Gawlik, Gregory A. Anderson et al. · Journal of Clinical Investigation · 2011 · 449 citations · Full text

, , +15

Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes

José Silva, Martin Köhler, Caroline Graff et al. · Nature Genetics · 2000 · 437 citations

, , +17

Tissue-specific knockout of the mouse <i>Pig-a</i> gene reveals important roles for GPI-anchored proteins in skin development

Masahito Tarutani, Satoshi Itami, Masaru Okabe et al. · Proceedings of the National Academy of Sciences · 1997 · 268 citations · Full text

, , +13

1–5 of 96

Authors

756

  1. NL
    Nils‐Göran Larsson

    Karolinska Institutet, Sweden

    5 publications · 907 citations

    5

    h-index

  2. JE
    Julie E. Goodwin

    Yale University, United States

    2 publications · 139 citations

    2

    h-index

  3. NW
    Nils Wierup

    Lund University, Sweden

    2 publications · 99 citations

    2

    h-index

  4. HK
    Ho‐Jin Koh

    University of South Carolina, United States

    2 publications · 108 citations

    2

    h-index

  5. MA
    Mark A. Magnuson

    Vanderbilt University, United States

    2 publications · 1.6K citations

    2

    h-index

1–5 of 756

Institutions

269

  1. Karolinska Institutet

    Stockholm, Sweden

    5 h-index

    23 publications

    5.1K citations

  2. The Ohio State University

    Columbus, United States

    4 h-index

    12 publications

    498 citations

  3. Mayo Clinic

    Rochester, United States

    4 h-index

    20 publications

    698 citations

  4. Baylor College of Medicine

    Houston, United States

    4 h-index

    5 publications

    553 citations

  5. University of California San Diego

    San Diego, United States

    3 h-index

    20 publications

    1.5K citations

  6. University of Freiburg

    Freiburg im Breisgau, Germany

    3 h-index

    23 publications

    1.2K citations

  7. Lund University

    Lund, Sweden

    3 h-index

    14 publications

    702 citations

  8. Friedrich-Alexander-Universität Erlangen-Nürnberg

    Erlangen, Germany

    3 h-index

    24 publications

    2K citations

1–8 of 269

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 6 publications · 950 citations

    6

    h-index

  2. PLoS ONE

    5 publications · 104 citations

    5

    h-index

  3. Circulation Research

    5 publications · 314 citations

    5

    h-index

  4. Nature Communications

    4 publications · 304 citations

    4

    h-index

  5. Molecular Endocrinology

    3 publications · 230 citations

    3

    h-index

1–5