Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes

Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

Paul E. Lacy, Mery Kostianovsky · Diabetes · 1967 · 2.8K citations

Life Sciences, Biochemistry, Physiology +14

Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice

Nils‐Göran Larsson, Jianming Wang, Hans Wilhelmsson et al. · Nature Genetics · 1998 · 1.6K citations

Life Sciences, Genetics, Molecular Biology +14

Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

Catherine Postic, Masakazu Shiota, Kevin D. Niswender et al. · Journal of Biological Chemistry · 1999 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +14

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

Rohit Kulkarni, Jens C. Brüning, Jonathon N. Winnay et al. · Cell · 1999 · 1.2K citations · Full text

Life Sciences, Endocrinology, Physiology +17

A Subtype of Diabetes Mellitus Associated with a Mutation of Mitochondrial DNA

Takashi Kadowaki, Hiroko Kadowaki, Yasumichi Mori et al. · New England Journal of Medicine · 1994 · 559 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17