Concepedia

Tissue-specific Gene Knockout

Tissue-Specific Gene Knockout is a genetic engineering technique that enables the targeted inactivation of a specific gene exclusively in a defined tissue or cell type, thereby allowing the study of gene function in a spatially restricted manner without affecting its expression in other tissues.

105

Publications

9.6K

Citations

740

Authors

246

Institutions

Publications per year

2017–2026

28

Variants

Conditional Knockout

Parents

Publications

105

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

Rohit Kulkarni, Jens C. Brüning, Jonathon N. Winnay et al. · Cell · 1999 · 1.2K citations · Full text

, , +17

Animal models in type 2 diabetes research: an overview.

K. K. Srinivasan, Poduri Ramarao · PubMed · 2007 · 724 citations

, , +17

Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes

José Silva, Martin Köhler, Caroline Graff et al. · Nature Genetics · 2000 · 437 citations

, , +17

Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation

Xiantuo Wu, Jian Wu, Jiapeng Huang et al. · Mechanisms of Development · 2001 · 398 citations

, , +12

A CRISPR/Cas9 Vector System for Tissue-Specific Gene Disruption in Zebrafish

Julien Ablain, Ellen M. Durand, Song Yang et al. · Developmental Cell · 2015 · 375 citations · Full text

, , +14

1–5 of 105

Authors

740

  1. NL
    Nils‐Göran Larsson

    Karolinska Institutet, Sweden

    4 publications · 659 citations

    4

    h-index

  2. BZ
    Bin Zhou

    Center for Excellence in Molecular Cell Science, China

    3 publications · 143 citations

    3

    h-index

  3. KL
    Kuo Liu

    Center for Excellence in Molecular Cell Science, China

    2 publications · 83 citations

    2

    h-index

  4. HM
    Henry M. Sucov

    University of Southern California, United States

    2 publications · 489 citations

    2

    h-index

  5. RA
    Rafael Andrade Buono

    University of Wisconsin–Madison, United States

    2 publications · 292 citations

    2

    h-index

1–5 of 740

Institutions

246

  1. Baylor College of Medicine

    Houston, United States

    7 h-index

    19 publications

    1.7K citations

  2. National Institutes of Health

    Bethesda, United States

    6 h-index

    12 publications

    978 citations

  3. Karolinska Institutet

    Stockholm, Sweden

    5 h-index

    20 publications

    3.9K citations

  4. University of Iowa

    Iowa City, United States

    4 h-index

    18 publications

    864 citations

  5. Harvard University

    Cambridge, United States

    4 h-index

    14 publications

    5.6K citations

  6. Yale University

    New Haven, United States

    4 h-index

    13 publications

    673 citations

  7. ShanghaiTech University

    Shanghai, China

    3 h-index

    8 publications

    431 citations

  8. Karolinska University Hospital

    Stockholm, Sweden

    3 h-index

    10 publications

    2.4K citations

1–8 of 246

Venues

  1. PLoS ONE

    8 publications · 303 citations

    8

    h-index

  2. Nucleic Acids Research

    5 publications · 449 citations

    5

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 993 citations

    4

    h-index

  4. Molecular and Cellular Biology

    MCB · 3 publications · 204 citations

    3

    h-index

  5. Scientific Reports

    3 publications · 180 citations

    3

    h-index

1–5