Antimicrobial Peptide LL-37 Drives Rosacea-Like Skin Inflammation in an NLRP3-Dependent Manner

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

Michael T. Heneka, Markus P. Kummer, Andrea Stutz et al. · Nature · 2012 · 2.9K citations · Full text

Life Sciences, Neurology, Neuroscience +14

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

Bolormaa Vandanmagsar, Yun‐Hee Youm, Anthony Ravussin et al. · Nature Medicine · 2011 · 2.6K citations · Full text

Life Sciences, Cell Biology, Immunology +14

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Raúl Muñoz-Planillo, Peter Kuffa, Giovanny J. Martínez-Colón et al. · Immunity · 2013 · 2.1K citations

Life Sciences, Immunology, Microbiology +16

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Teresa Fernandes‐Alnemri, Je‐Wook Yu, Pinaki Datta et al. · Nature · 2009 · 1.8K citations · Full text

Life Sciences, Immunology, Molecular Biology +12

Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells

De Yang, Qian Chen, Albert P. Schmidt et al. · The Journal of Experimental Medicine · 2000 · 1.2K citations · Full text

Life Sciences, Immunology, Cell Signaling +16