Concepedia

Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

Daxiong Li, Chunsheng Zhang, Wei Ding, Siming Huang, Le Yu, Nan Lu, Wenkai Pan, Yiming Li, Erik De Clercq, Christophe Pannecouque,

Chinese Chemical Letters · 2020 · 12 citations · 23 references

DOIFull text

Open access

Concepts

References

23

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

Rudi Pauwels, Jan Balzarini, Masanori Baba et al. · Journal of Virological Methods · 1988 · 1.6K citations

, , +12

Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later

Christophe Pannecouque, Dirk Daelemans, Erik De Clercq · Nature Protocols · 2008 · 349 citations

, , +14

Design, Synthesis, and Evaluation of Thiophene[3,2-<i>d</i>]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles

Dongwei Kang, Zengjun Fang, Zhenyu Li et al. · Journal of Medicinal Chemistry · 2016 · 135 citations · Full text

, , +16

5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3,4-dihydropyrimidin-4(3<i>H</i>)-ones:  Novel Potent and Selective Dihydro-alkoxy-benzyl-oxopyrimidine Derivatives

Antonello Mai, Marino Artico, Gianluca Sbardella et al. · Journal of Medicinal Chemistry · 1999 · 104 citations · Full text

, , +10

Dihydro(alkylthio)(naphthylmethyl)oxopyrimidines:  Novel Non-Nucleoside Reverse Transcriptase Inhibitors of the <i>S</i>-DABO Series

Antonello Mai, Marino Artico, Gianluca Sbardella et al. · Journal of Medicinal Chemistry · 1997 · 98 citations · Full text

, , +17