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SIRT1 is downregulated by autophagy in senescence and ageing

Caiyue Xu, Lu Wang, Parinaz Fozouni, Gry Evjen, Vemika Chandra, Jing Jiang, Congcong Lu, Michael C. Nicastri, Corey Bretz, Jeffrey D. Winkler,

Nature Cell Biology · 2020 · 463 citations · 30 references

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p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Serhiy Pankiv, Terje Høyvarde Clausen, Trond Lamark et al. · Journal of Biological Chemistry · 2007 · 4.5K citations · Full text

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Darren J. Baker, Tobias Wijshake, Tamar Tchkonia et al. · Nature · 2011 · 3.6K citations · Full text

, , +13

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Heidi A. Tissenbaum, Leonard Guarente · Nature · 2001 · 1.9K citations

, , +10

Requirement of NAD and <i>SIR2</i> for Life-Span Extension by Calorie Restriction in <i>Saccharomyces cerevisiae</i>

Su-Ju Lin, Pierre‐Antoine Defossez, Leonard Guarente · Science · 2000 · 1.8K citations

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

Blanka Rogina, Stephen L. Helfand · Proceedings of the National Academy of Sciences · 2004 · 1.4K citations · Full text

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