Jeffrey D. Winkler

SIRT1 is downregulated by autophagy in senescence and ageing

Caiyue Xu, Lu Wang, Parinaz Fozouni et al. · Nature Cell Biology · 2020 · 463 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +10

Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma

Xiao-Hong Ma, Sheng-Fu Piao, Souvik Dey et al. · Journal of Clinical Investigation · 2014 · 456 citations · Full text

Life Sciences, Oncology, Pharmacology +16

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

Quentin McAfee, Zhihui Zhang, Arabinda Samanta et al. · Proceedings of the National Academy of Sciences · 2012 · 415 citations · Full text

Medicine, Oncology, Pharmacology +17

Reduction of Clofazimine by Mycobacterial Type 2 NADH:Quinone Oxidoreductase

Takahiro Yano, Sacha Kassovska‐Bratinova, J. S. Teh et al. · Journal of Biological Chemistry · 2010 · 342 citations · Full text

Life Sciences, Biochemistry, Microbiology +17

De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers

Sungwook Choi, André K. Isaacs, Dylan J. Clements et al. · Proceedings of the National Academy of Sciences · 2009 · 308 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +17