Concepedia

Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer

Cuige Zhu, Anna Rogers, Karama Asleh, Jennifer Won, Dongxia Gao, Samuel Leung, Shan Li, Kiran Vij, Jian Zhu, Jason M. Held,

Cell Reports · 2020 · 33 citations · 66 references

DOIFull text

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Concepts

Abstract

phosphorylation is a DDR-specific enhancer of VCP function and a potential predictive biomarker for chemotherapy treatments.

References

66

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Hannah Farmer, Nuala McCabe, Christopher J. Lord et al. · Nature · 2005 · 6.7K citations

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Helen E. Bryant, Niklas Schultz, Huw D. Thomas et al. · Nature · 2005 · 5.2K citations

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Strategies for subtypes—dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011

Aron Goldhirsch, W. C. Wood, Alan S. Coates et al. · Annals of Oncology · 2011 · 3.9K citations · Full text

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ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

Shuhei Matsuoka, Bryan A. Ballif, Agata Smogorzewska et al. · Science · 2007 · 3.1K citations

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Ki67 Index, HER2 Status, and Prognosis of Patients With Luminal B Breast Cancer

Maggie C.U. Cheang, Stephen Chia, David Voduc et al. · JNCI Journal of the National Cancer Institute · 2009 · 2.2K citations · Full text

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