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A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects

EngineeringGenome SurgeryNatural SciencesHigh On-target ActivitySynthetic BiologyMolecular BiologyDna ReplicationCytosine Base EditorRna Off-target EffectsGene EditingAntisense TherapyGene ExpressionOff-target EffectGenome EditingBiomolecular Engineering