Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos

Erwei Zuo, Yidi Sun, Wei Wu, +7

Science

Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis

Changyang Zhou, Yidi Sun, Rui Yan, +11

Nature

Off-target Rna MutationGeneticsMolecular BiologyGenetic EngineeringGene Editing +5

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

Haibo Zhou, Jinlin Su, Xinde Hu, +19

Cell

Neurodegenerative DiseasesNeuroregenerationMedicineGene EditingNeurology +10

Integrated Omics of Metastatic Colorectal Cancer

Chen Li, Yidi Sun, Guanyu Yu, +19

Cancer Cell

MedicineMulti-omics StudyColorectal CancerPathologyMetastatic Colorectal Cancer +4

In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9-activator transgenic mice

Haibo Zhou, Junlai Liu, Changyang Zhou, +19

Nature Neuroscience

Transcriptional RegulationSystems BiologyIn Vivo Gene TherapyMultiple GenesCrispr–dcas9-activator Transgenic Mice +10

One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs

Erwei Zuo, Yijun Cai, Kui Li, +26

Cell Research

EngineeringGeneticsOne-step GenerationMolecular GeneticsMonkey Embryos +15

CRISPR/Cas9-mediated targeted chromosome elimination

Erwei Zuo, Xiaona Huo, Xuan Yao, +15

Genome biology

Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex

Ao Chen, Yidi Sun

Cell

NeurogenomicsMacaque CortexBrain MappingBrain OrganizationSpatial Omics +20

A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects

Erwei Zuo, Yidi Sun, Tanglong Yuan, +8

Nature Methods

EngineeringGenome SurgeryNatural SciencesHigh On-target ActivitySynthetic Biology +10

Pharmaco-proteogenomic characterization of liver cancer organoids for precision oncology

Shuyi Ji, Feng Li, Zile Fu, +31

Science Translational Medicine

Tumor BiologyMedicineLiver PhysiologyHepatobiliary TumorPharmacology +10