Concepedia

Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches

Majda Bratovič, Ines Fonfara, Krzysztof Chylinski, Eric J. C. Gálvez, Timothy J. Sullivan, Stefan Boerno, Bernd Timmermann, Michael Boettcher, Emmanuelle Charpentier

Nature Chemical Biology · 2020 · 76 citations · 46 references

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46

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Martin Jínek, Krzysztof Chylinski, Ines Fonfara et al. · Science · 2012 · 17.3K citations · Full text

, , +17

Studies on transformation of Escherichia coli with plasmids

Douglas Hanahan · Journal of Molecular Biology · 1983 · 11.3K citations

, , +12

Cas9–crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

Giedrius Gasiūnas, Rodolphe Barrangou, Philippe Horvath et al. · Proceedings of the National Academy of Sciences · 2012 · 2.8K citations · Full text

, , +14

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

Benjamin P. Kleinstiver, Vikram Pattanayak, Michelle S. Prew et al. · Nature · 2016 · 2.7K citations · Full text

, , +14

CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

Elitza Deltcheva, Krzysztof Chylinski, Cynthia M. Sharma et al. · Nature · 2011 · 2.6K citations · Full text

, , +10